1. What is Knee Osteoarthritis?

Knee osteoarthritis is a complex condition that significantly impacts the daily life of patients. It used to be more prevalent among older adults. Still, the busy, less healthy lifestyle has led to an increasing trend among younger individuals. If not treated properly, this condition can result in lifelong disability and limited mobility.

Knee osteoarthritis, also known as knee cartilage degeneration, is where the natural cushioning between the joints (cartilage) deteriorates. When this happens, the bones in the joint rub together more forcefully, leading to pain, discomfort, swelling, and reduced mobility. Bone spurs may also develop around the knee area.

The damaged cartilage, along with the degenerative process and decreased joint fluid production, fails to compensate for the lost cartilage over time adequately.

2. Causes of Knee Osteoarthritis?

Weight-related factors

Excess weight and obesity can increase the pressure on all joints, particularly the knees. Studies have shown that every 0.45 kg increase in body weight can lead to a 1.35 – 1.8 kg increase in knee joint load. Therefore, managing weight is crucial to preserving knee joints at any age.

Genetic factors

Genetic mutations can predispose individuals to early-onset knee joint degeneration, even at a young age. Abnormal bone structure around the knee joint can also make the knee cartilage more susceptible to deterioration.


Women over 45 have a 1.5 – 2 times higher risk of developing knee osteoarthritis than men. Commonly affected joints include the hip, knee, and spine. Women have a weaker ligament system around the knee, making them more prone to injury during physical activity. Additionally, women’s broader pelvic bone structure, especially after childbirth, can contribute to knee osteoarthritis.

Athletic activities

Athletes who engage in sports like soccer, tennis, and track and field are at higher risk of developing knee joint problems due to the repetitive and strenuous demands on their knee joints. The risk increases further if athletes experience injuries during training.

3. Signs and Symptoms of Knee Osteoarthritis?


Knee osteoarthritis progresses through distinct stages, each characterized by specific symptoms:

  • Stage 1: During this stage, there are usually no noticeable signs of cartilage damage. Patients may not experience pain or discomfort due to minimal erosion between joint components.

  • Stage 2: Considered a mild stage of the condition, X-rays of the knee joint may still show a relatively normal space between bones without significant friction. However, patients may notice early symptoms, such as aching after prolonged walking or running, increased joint pain when stationary for a few hours, or discomfort while kneeling or bending.

  • Stage 3: Individuals in this stage often experience frequent pain when walking or running. Stiffness may occur after extended periods of sitting or waking in the morning. Some patients may even feel numbness and stiffness when sitting for prolonged periods, making movement difficult.

  • Stage 4: knee osteoarthritis is considered severe. At this point, patients typically experience intense and persistent pain during movement, and their knees may become stiff and occasionally immobile. The joint space significantly narrows, and the cartilage is nearly gone, causing bones to rub against each other. If left untreated, complications may include chronic pain, joint deformity, mobility difficulties, muscle atrophy, and paralysis.

4. Treatment Options for Knee Osteoarthritis

In particular, according to the AMIO Institute of International Regenerative Medicine Doctors’ Council, if knee osteoarthritis is not detected early and treated properly, the disease will quickly progress to a severe stage and become dangerous due to complications. Complications such as:

  • Persistent pain
  • Knee deformity
  • Difficulty walking
  • Muscle atrophy, paralysis


5. Treatment Options for Knee Osteoarthritis:

The diagnosis of knee osteoarthritis begins with a comprehensive health assessment, including a review of your medical history and recent symptoms. Further clinical tests may be conducted to assess your condition accurately. Treatment options may include:

  • Arthroscopic debridement: Used for patients with pain and limited mobility who have not responded well to conservative treatments.
  • Autologous chondrocyte implantation (ACI): Recommended for young patients with isolated cartilage defects resulting from trauma or specific anatomical abnormalities.
  • Total knee replacement: Reserved for patients in stages 3 or 4 who have not responded to other treatments. It is a major surgery with high associated costs.
  • Bio Nano Cell stem cell therapy: A cutting-edge medical advancement that offers a new way to treat knee osteoarthritis. AMIO StemCell’s Bio Nano Cell therapy utilizes the latest medical breakthroughs to provide a standardized American approach to knee osteoarthritis treatment using stem cell technology.

The secret to helping knee joints last forever at age 40

Leveraging cutting-edge advancements in modern medicine, AMIO StemCell offers a standardized American approach to treating ankle joint degeneration using Bio Nano Cell therapy, a form of stem cell therapy.

Bio Nano Cell operates on automatic search, repair, and complete replacement of damaged cells caused by aging with new, healthy cells. This therapy offers several benefits:

– Rapid Pain Reduction: Significantly reduces symptoms like pain, stiffness, and joint rigidity.

– Accelerated Cartilage Regeneration: Enhances the body’s natural healing processes, forming new cartilage and bolstering the body’s self-healing capabilities.

– Improved Joint Lubrication: Enhances joint lubrication, eliminating dry joint conditions.

– Slows Down the Aging Process: Slows down joint cartilage aging and damage.

– Collagen Supplementation: Stabilizes the joint cartilage structure.

– Enhanced Mobility: Improves joint mobility, durability, and flexibility.

Notably, this is a treatment for joint degeneration that does not require medication or surgery and allows patients to continue their daily activities without needing prolonged rest. Bio Nano Cell therapy is considered a leading choice for joint degeneration treatment in the United States and Europe.

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